Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1866912..1867743 | Replicon | chromosome |
| Accession | NZ_CP060880 | ||
| Organism | Escherichia coli strain EC26 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | H9209_RS08915 | Protein ID | WP_039268420.1 |
| Coordinates | 1866912..1867286 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | F4THW5 |
| Locus tag | H9209_RS08920 | Protein ID | WP_001313071.1 |
| Coordinates | 1867375..1867743 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9209_RS08875 (1862308) | 1862308..1863474 | + | 1167 | WP_001310935.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| H9209_RS08880 (1863593) | 1863593..1864066 | + | 474 | WP_001105393.1 | DNA gyrase inhibitor SbmC | - |
| H9209_RS08885 (1864264) | 1864264..1865322 | + | 1059 | WP_001200905.1 | FUSC family protein | - |
| H9209_RS08890 (1865494) | 1865494..1865823 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| H9209_RS08895 (1865924) | 1865924..1866058 | - | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| H9209_RS08900 (1866160) | 1866160..1866306 | + | 147 | Protein_1746 | transposase domain-containing protein | - |
| H9209_RS08905 (1866595) | 1866595..1866675 | - | 81 | Protein_1747 | hypothetical protein | - |
| H9209_RS08910 (1866721) | 1866721..1866915 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| H9209_RS08915 (1866912) | 1866912..1867286 | - | 375 | WP_039268420.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| H9209_RS08920 (1867375) | 1867375..1867743 | - | 369 | WP_001313071.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H9209_RS08925 (1867823) | 1867823..1868044 | - | 222 | WP_000692301.1 | DUF987 domain-containing protein | - |
| H9209_RS08930 (1868107) | 1868107..1868583 | - | 477 | WP_001186726.1 | RadC family protein | - |
| H9209_RS08935 (1868599) | 1868599..1869078 | - | 480 | WP_000860076.1 | antirestriction protein | - |
| H9209_RS08940 (1869160) | 1869160..1869981 | - | 822 | WP_001234530.1 | DUF932 domain-containing protein | - |
| H9209_RS08945 (1870202) | 1870202..1870534 | - | 333 | Protein_1755 | hypothetical protein | - |
| H9209_RS08955 (1871380) | 1871380..1871568 | + | 189 | Protein_1757 | IS4 family transposase | - |
| H9209_RS08960 (1871547) | 1871547..1871720 | + | 174 | Protein_1758 | cobalamin biosynthesis protein | - |
| H9209_RS08965 (1871872) | 1871872..1872417 | + | 546 | WP_000973176.1 | bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14000.00 Da Isoelectric Point: 7.1333
>T171294 WP_039268420.1 NZ_CP060880:c1867286-1866912 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T171294 NZ_CP077877:1772111-1772287 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13498.23 Da Isoelectric Point: 5.8696
>AT171294 WP_001313071.1 NZ_CP060880:c1867743-1867375 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT171294 NZ_CP077877:c1772449-1772275 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|