Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3526023..3526641 Replicon chromosome
Accession NZ_CP060873
Organism Escherichia coli strain EC27

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H9210_RS17100 Protein ID WP_001291435.1
Coordinates 3526423..3526641 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H9210_RS17095 Protein ID WP_000344800.1
Coordinates 3526023..3526397 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9210_RS17085 (3521112) 3521112..3522305 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H9210_RS17090 (3522328) 3522328..3525477 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
H9210_RS17095 (3526023) 3526023..3526397 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H9210_RS17100 (3526423) 3526423..3526641 + 219 WP_001291435.1 HHA domain-containing protein Toxin
H9210_RS17105 (3526813) 3526813..3527364 + 552 WP_000102568.1 maltose O-acetyltransferase -
H9210_RS17110 (3527480) 3527480..3527950 + 471 WP_000136192.1 YlaC family protein -
H9210_RS17115 (3528114) 3528114..3529664 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H9210_RS17120 (3529706) 3529706..3530059 - 354 WP_000878140.1 DUF1428 domain-containing protein -
H9210_RS17130 (3530438) 3530438..3530749 + 312 WP_000409911.1 MGMT family protein -
H9210_RS17135 (3530780) 3530780..3531352 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T171275 WP_001291435.1 NZ_CP060873:3526423-3526641 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171275 NZ_CP077870:c2540714-2540607 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT171275 WP_000344800.1 NZ_CP060873:3526023-3526397 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT171275 NZ_CP077870:2540530-2540590 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References