Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3877773..3878605 Replicon chromosome
Accession NZ_CP060867
Organism Escherichia coli strain EC29

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag H9211_RS18750 Protein ID WP_000854765.1
Coordinates 3878231..3878605 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag H9211_RS18745 Protein ID WP_001295723.1
Coordinates 3877773..3878141 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9211_RS18710 (3873437) 3873437..3874117 + 681 WP_001282921.1 WYL domain-containing protein -
H9211_RS18715 (3874265) 3874265..3874942 + 678 WP_001097302.1 hypothetical protein -
H9211_RS18720 (3874948) 3874948..3875181 + 234 WP_001278293.1 DUF905 family protein -
H9211_RS18725 (3875271) 3875271..3876089 + 819 WP_001175165.1 DUF932 domain-containing protein -
H9211_RS18730 (3876355) 3876355..3876834 + 480 WP_057109541.1 antirestriction protein -
H9211_RS18735 (3876850) 3876850..3877326 + 477 WP_001186774.1 RadC family protein -
H9211_RS18740 (3877389) 3877389..3877610 + 222 WP_000692341.1 DUF987 domain-containing protein -
H9211_RS18745 (3877773) 3877773..3878141 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9211_RS18750 (3878231) 3878231..3878605 + 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
H9211_RS18755 (3878605) 3878605..3878808 + 204 WP_001398797.1 DUF5983 family protein -
H9211_RS18760 (3878833) 3878833..3879027 + 195 WP_024181941.1 DUF957 domain-containing protein -
H9211_RS18765 (3879112) 3879112..3879954 + 843 WP_022645115.1 DUF4942 domain-containing protein -
H9211_RS18770 (3880235) 3880235..3880771 - 537 WP_000942785.1 GspM family type II secretion system protein YghD -
H9211_RS18775 (3880773) 3880773..3881951 - 1179 WP_000094991.1 type II secretion system protein GspL -
H9211_RS18780 (3881948) 3881948..3882925 - 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
H9211_RS18785 (3882928) 3882928..3883527 - 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T171241 WP_000854765.1 NZ_CP060867:3878231-3878605 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T171241 NZ_CP077867:c788713-788393 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT171241 WP_001295723.1 NZ_CP060867:3877773-3878141 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171241 NZ_CP077867:c788925-788716 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A7ZVJ9


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References