Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1180913..1181531 Replicon chromosome
Accession NZ_CP060867
Organism Escherichia coli strain EC29

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H9211_RS05730 Protein ID WP_001291435.1
Coordinates 1180913..1181131 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H9211_RS05735 Protein ID WP_000344800.1
Coordinates 1181157..1181531 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9211_RS05695 (1176202) 1176202..1176774 + 573 WP_000779831.1 YbaY family lipoprotein -
H9211_RS05700 (1176805) 1176805..1177116 - 312 WP_000409911.1 MGMT family protein -
H9211_RS05710 (1177495) 1177495..1177848 + 354 WP_000878140.1 DUF1428 domain-containing protein -
H9211_RS05715 (1177890) 1177890..1179440 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H9211_RS05720 (1179604) 1179604..1180074 - 471 WP_000136192.1 YlaC family protein -
H9211_RS05725 (1180190) 1180190..1180741 - 552 WP_000102564.1 maltose O-acetyltransferase -
H9211_RS05730 (1180913) 1180913..1181131 - 219 WP_001291435.1 HHA domain-containing protein Toxin
H9211_RS05735 (1181157) 1181157..1181531 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H9211_RS05740 (1182077) 1182077..1185226 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
H9211_RS05745 (1185249) 1185249..1186442 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T171226 WP_001291435.1 NZ_CP060867:c1181131-1180913 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171226 NZ_CP077863:2115812-2115916 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT171226 WP_000344800.1 NZ_CP060867:c1181531-1181157 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT171226 NZ_CP077863:c2116075-2115911 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References