Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 200144..200673 Replicon chromosome
Accession NZ_CP060861
Organism Enterococcus faecium strain AML0157

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag IA041_RS00985 Protein ID WP_002296560.1
Coordinates 200407..200673 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag IA041_RS00980 Protein ID WP_002296559.1
Coordinates 200144..200407 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IA041_RS00970 197518..199341 + 1824 WP_002294202.1 APC family permease -
IA041_RS00975 199483..199668 - 186 WP_002296558.1 transcriptional regulator -
IA041_RS00980 200144..200407 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IA041_RS00985 200407..200673 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
IA041_RS00990 200874..201362 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
IA041_RS00995 201903..202574 - 672 WP_002302663.1 ABC transporter permease -
IA041_RS01000 202571..203488 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
IA041_RS01005 203485..204126 - 642 WP_002293405.1 ABC transporter permease -
IA041_RS01010 204130..205305 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T171215 WP_002296560.1 NZ_CP060861:200407-200673 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T171215 NZ_CP077861:c674261-673899 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT171215 WP_002296559.1 NZ_CP060861:200144-200407 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT171215 NZ_CP077861:c674428-674258 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References