Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84083..85706 Replicon plasmid p453-MDR
Accession NZ_CP060856
Organism Salmonella enterica strain 453

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag IAQ58_RS22880 Protein ID WP_000088046.1
Coordinates 84381..85706 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag IAQ58_RS22875 Protein ID WP_024136327.1
Coordinates 84083..84376 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ58_RS22850 (IAQ58_22675) 79955..81196 + 1242 WP_001053338.1 VWA domain-containing protein -
IAQ58_RS23660 81287..81418 + 132 WP_000374059.1 hypothetical protein -
IAQ58_RS22855 (IAQ58_22680) 81759..82040 - 282 WP_000077926.1 hypothetical protein -
IAQ58_RS22860 (IAQ58_22685) 82090..82281 - 192 WP_000398480.1 hypothetical protein -
IAQ58_RS22865 (IAQ58_22690) 82373..82714 - 342 WP_001151575.1 hypothetical protein -
IAQ58_RS22870 (IAQ58_22695) 83087..83479 + 393 WP_000341066.1 hypothetical protein -
IAQ58_RS22875 (IAQ58_22700) 84083..84376 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
IAQ58_RS22880 (IAQ58_22705) 84381..85706 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
IAQ58_RS22885 (IAQ58_22710) 85767..85973 + 207 WP_000134171.1 hypothetical protein -
IAQ58_RS22890 (IAQ58_22715) 86075..86485 + 411 WP_000985911.1 hypothetical protein -
IAQ58_RS22895 (IAQ58_22720) 86498..87313 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
IAQ58_RS22900 (IAQ58_22725) 87597..88294 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
IAQ58_RS22905 (IAQ58_22730) 88338..89003 - 666 WP_000490638.1 hypothetical protein -
IAQ58_RS22910 (IAQ58_22735) 89061..89441 - 381 WP_001426317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / qnrS1 / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / dfrA14 / floR / blaCTX-M-65 - 1..220699 220699
- flank IS/Tn - - 87597..87872 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T171214 WP_000088046.1 NZ_CP060856:84381-85706 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T171214 NZ_CP077861:c522379-522227 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT171214 WP_024136327.1 NZ_CP060856:84083-84376 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT171214 NZ_CP077861:c523003-522404 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References