Detailed information of TA system TA171211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4035034..4035550
• Replicon: chromosome
• Accession: NZ_CP060855
• Organism: Salmonella enterica strain 453

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAQ58_RS19395
• Protein ID: WP_133323120.1
• Coordinates: 4035034..4035318 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAQ58_RS19400
• Protein ID: WP_000212724.1
• Coordinates: 4035308..4035550 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAQ58_RS19380 (4030246)	4030246..4031898	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
IAQ58_RS19385 (4032307)	4032307..4034445	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAQ58_RS19390 (4034566)	4034566..4035030	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAQ58_RS19395 (4035034)	4035034..4035318	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAQ58_RS19400 (4035308)	4035308..4035550	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAQ58_RS19405 (4035628)	4035628..4037541	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAQ58_RS19410 (4037558)	4037558..4038298	-	741	WP_023229489.1	KDGP aldolase family protein	-
IAQ58_RS19415 (4038295)	4038295..4039413	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAQ58_RS19420 (4039397)	4039397..4040530	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171211 WP_133323120.1 NZ_CP060855:c4035318-4035034 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171211 NZ_CP077860:c1433734-1433468 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171211 WP_000212724.1 NZ_CP060855:c4035550-4035308 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171211 NZ_CP077860:c1433991-1433734 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5