Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3342056..3342676 Replicon chromosome
Accession NZ_CP060855
Organism Salmonella enterica strain 453

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAQ58_RS16220 Protein ID WP_001280991.1
Coordinates 3342458..3342676 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAQ58_RS16215 Protein ID WP_000344807.1
Coordinates 3342056..3342430 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ58_RS16205 (3337195) 3337195..3338388 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IAQ58_RS16210 (3338411) 3338411..3341560 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAQ58_RS16215 (3342056) 3342056..3342430 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAQ58_RS16220 (3342458) 3342458..3342676 + 219 WP_001280991.1 HHA domain-containing protein Toxin
IAQ58_RS16225 (3342855) 3342855..3343406 + 552 WP_001278793.1 maltose O-acetyltransferase -
IAQ58_RS16230 (3343522) 3343522..3343992 + 471 WP_000136183.1 YlaC family protein -
IAQ58_RS16235 (3344048) 3344048..3344188 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAQ58_RS16240 (3344194) 3344194..3344454 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAQ58_RS16245 (3344679) 3344679..3346229 + 1551 WP_000213138.1 EAL domain-containing protein -
IAQ58_RS16255 (3346460) 3346460..3346849 + 390 WP_000961285.1 MGMT family protein -
IAQ58_RS16260 (3346882) 3346882..3347451 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171207 WP_001280991.1 NZ_CP060855:3342458-3342676 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171207 NZ_CP077860:c1058734-1058525 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171207 WP_000344807.1 NZ_CP060855:3342056-3342430 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171207 NZ_CP077860:c1059039-1058746 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References