Detailed information of TA system TA171198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1008803..1009617
• Replicon: chromosome
• Accession: NZ_CP060855
• Organism: Salmonella enterica strain 453

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: IAQ58_RS04810
• Protein ID: WP_000971651.1
• Coordinates: 1008803..1009330 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: IAQ58_RS04815
• Protein ID: WP_000855694.1
• Coordinates: 1009327..1009617 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAQ58_RS04775 (1005078)	1005078..1005476	+	399	Protein_938	cytoplasmic protein	-
IAQ58_RS04780 (1005667)	1005667..1005906	+	240	Protein_939	hypothetical protein	-
IAQ58_RS04785 (1006063)	1006063..1006518	+	456	WP_241468791.1	hypothetical protein	-
IAQ58_RS04790 (1006557)	1006557..1006730	+	174	WP_241468792.1	hypothetical protein	-
IAQ58_RS04795 (1006757)	1006757..1007251	+	495	WP_020899151.1	hypothetical protein	-
IAQ58_RS04800 (1007423)	1007423..1008079	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
IAQ58_RS04805 (1008312)	1008312..1008730	+	419	Protein_944	transposase	-
IAQ58_RS04810 (1008803)	1008803..1009330	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
IAQ58_RS04815 (1009327)	1009327..1009617	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
IAQ58_RS04820 (1010211)	1010211..1010537	+	327	WP_000393295.1	hypothetical protein	-
IAQ58_RS04825 (1010810)	1010810..1011157	-	348	WP_001555786.1	DUF1493 family protein	-
IAQ58_RS04830 (1011142)	1011142..1011591	-	450	WP_133322517.1	hypothetical protein	-
IAQ58_RS04835 (1012023)	1012023..1012466	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
IAQ58_RS04840 (1012923)	1012923..1013573	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1007423..1018886	11463
	-	flank	IS/Tn	-	-	1008554..1008730	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T171198 WP_000971651.1 NZ_CP060855:c1009330-1008803 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T171198 NZ_CP077859:2567438-2567800 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT171198 WP_000855694.1 NZ_CP060855:c1009617-1009327 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT171198 NZ_CP077859:2567271-2567441 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7