Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842498..843158 Replicon chromosome
Accession NZ_CP060855
Organism Salmonella enterica strain 453

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag IAQ58_RS04060 Protein ID WP_000244757.1
Coordinates 842745..843158 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag IAQ58_RS04055 Protein ID WP_000351186.1
Coordinates 842498..842764 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ58_RS04035 (838426) 838426..839859 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
IAQ58_RS04040 (840018) 840018..840329 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
IAQ58_RS04045 (840493) 840493..841152 + 660 WP_000250289.1 hemolysin III family protein -
IAQ58_RS04050 (841268) 841268..842248 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
IAQ58_RS04055 (842498) 842498..842764 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
IAQ58_RS04060 (842745) 842745..843158 + 414 WP_000244757.1 protein YgfX Toxin
IAQ58_RS04065 (843211) 843211..843732 - 522 WP_001055885.1 flavodoxin FldB -
IAQ58_RS04070 (843845) 843845..844741 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
IAQ58_RS04075 (844765) 844765..845478 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IAQ58_RS04080 (845484) 845484..847217 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T171197 WP_000244757.1 NZ_CP060855:842745-843158 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T171197 NZ_CP077859:2546332-2546541 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT171197 WP_000351186.1 NZ_CP060855:842498-842764 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT171197 NZ_CP077859:2546027-2546320 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References