Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2542795..2543415 Replicon chromosome
Accession NZ_CP060849
Organism Salmonella enterica strain 724

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR31_RS12160 Protein ID WP_001280991.1
Coordinates 2542795..2543013 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR31_RS12165 Protein ID WP_000344807.1
Coordinates 2543041..2543415 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR31_RS12120 (2538020) 2538020..2538589 + 570 WP_000779802.1 YbaY family lipoprotein -
IAR31_RS12125 (2538622) 2538622..2539011 - 390 WP_000961285.1 MGMT family protein -
IAR31_RS12135 (2539242) 2539242..2540792 - 1551 WP_000213138.1 EAL domain-containing protein -
IAR31_RS12140 (2541017) 2541017..2541277 + 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAR31_RS12145 (2541283) 2541283..2541423 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR31_RS12150 (2541479) 2541479..2541949 - 471 WP_000136183.1 YlaC family protein -
IAR31_RS12155 (2542065) 2542065..2542616 - 552 WP_001278793.1 maltose O-acetyltransferase -
IAR31_RS12160 (2542795) 2542795..2543013 - 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR31_RS12165 (2543041) 2543041..2543415 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR31_RS12170 (2543911) 2543911..2547060 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR31_RS12175 (2547083) 2547083..2548276 - 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171167 WP_001280991.1 NZ_CP060849:c2543013-2542795 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171167 NZ_CP077856:2643240-2643491 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171167 WP_000344807.1 NZ_CP060849:c2543415-2543041 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171167 NZ_CP077856:2643481-2643663 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References