Detailed information of TA system TA171163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1847274..1847790
• Replicon: chromosome
• Accession: NZ_CP060849
• Organism: Salmonella enterica strain 724

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAR31_RS08970
• Protein ID: WP_133323120.1
• Coordinates: 1847506..1847790 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAR31_RS08965
• Protein ID: WP_000212724.1
• Coordinates: 1847274..1847516 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR31_RS08945 (1842294)	1842294..1843427	+	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-
IAR31_RS08950 (1843411)	1843411..1844529	+	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAR31_RS08955 (1844526)	1844526..1845266	+	741	WP_023229489.1	KDGP aldolase family protein	-
IAR31_RS08960 (1845283)	1845283..1847196	+	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAR31_RS08965 (1847274)	1847274..1847516	+	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAR31_RS08970 (1847506)	1847506..1847790	+	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR31_RS08975 (1847794)	1847794..1848258	-	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAR31_RS08980 (1848379)	1848379..1850517	-	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAR31_RS08985 (1850926)	1850926..1852578	-	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171163 WP_133323120.1 NZ_CP060849:1847506-1847790 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171163 NZ_CP077856:2232669-2232935 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171163 WP_000212724.1 NZ_CP060849:1847274-1847516 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171163 NZ_CP077856:2232418-2232669 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5