Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 986184..986944 Replicon chromosome
Accession NZ_CP060849
Organism Salmonella enterica strain 724

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag IAR31_RS04895 Protein ID WP_000533909.1
Coordinates 986184..986669 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag IAR31_RS04900 Protein ID WP_000965889.1
Coordinates 986657..986944 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR31_RS04865 (981255) 981255..981917 + 663 WP_000747548.1 OmpA family lipoprotein -
IAR31_RS04870 (982136) 982136..983110 + 975 WP_000804681.1 glyoxylate/hydroxypyruvate reductase GhrB -
IAR31_RS04875 (983160) 983160..983870 - 711 WP_000190524.1 DUF3053 domain-containing protein -
IAR31_RS04880 (984309) 984309..984599 + 291 WP_000455790.1 HTH-type transcriptional regulator -
IAR31_RS04885 (984887) 984887..985099 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
IAR31_RS04890 (985273) 985273..985812 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
IAR31_RS04895 (986184) 986184..986669 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
IAR31_RS04900 (986657) 986657..986944 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
IAR31_RS04905 (987127) 987127..987780 + 654 WP_001139163.1 LysE family translocator -
IAR31_RS04910 (987917) 987917..988816 - 900 WP_000462482.1 LysR family transcriptional regulator -
IAR31_RS04915 (988922) 988922..990082 + 1161 WP_000107288.1 mandelate racemase/muconate lactonizing enzyme family protein -
IAR31_RS04920 (990270) 990270..991598 + 1329 WP_000200570.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T171160 WP_000533909.1 NZ_CP060849:c986669-986184 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T171160 NZ_CP077856:1082770-1082958 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT171160 WP_000965889.1 NZ_CP060849:c986944-986657 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT171160 NZ_CP077856:1082481-1082741 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References