Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 882389..882976 Replicon chromosome
Accession NZ_CP060849
Organism Salmonella enterica strain 724

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag IAR31_RS04440 Protein ID WP_133322382.1
Coordinates 882389..882742 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag IAR31_RS04445 Protein ID WP_001520924.1
Coordinates 882755..882976 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR31_RS04420 (877908) 877908..878978 - 1071 WP_001646570.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
IAR31_RS04425 (878980) 878980..879825 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
IAR31_RS04430 (879822) 879822..880709 - 888 WP_000094074.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
IAR31_RS04435 (880814) 880814..882130 - 1317 WP_133322384.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
IAR31_RS04440 (882389) 882389..882742 - 354 WP_133322382.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IAR31_RS04445 (882755) 882755..882976 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IAR31_RS04450 (883107) 883107..883820 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
IAR31_RS04455 (883822) 883822..884589 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
IAR31_RS04460 (884586) 884586..885863 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
IAR31_RS04465 (885860) 885860..886786 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
IAR31_RS04470 (886846) 886846..887955 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 877171..885863 8692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-109)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13015.16 Da        Isoelectric Point: 6.7252

>T171159 WP_133322382.1 NZ_CP060849:c882742-882389 [Salmonella enterica]
ISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALFITLLF
LKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 354 bp

>T171159 NZ_CP077856:c55866-55771 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT171159 WP_001520924.1 NZ_CP060849:c882976-882755 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT171159 NZ_CP077856:55686-55743 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References