Detailed information of TA system TA171157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 160727..161541
• Replicon: chromosome
• Accession: NZ_CP060849
• Organism: Salmonella enterica strain 724

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: IAR31_RS00880
• Protein ID: WP_000971651.1
• Coordinates: 161014..161541 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: IAR31_RS00875
• Protein ID: WP_000855694.1
• Coordinates: 160727..161017 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR31_RS00850 (156771)	156771..157421	-	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-
IAR31_RS00855 (157878)	157878..158321	+	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
IAR31_RS00860 (158753)	158753..159202	+	450	WP_133322517.1	hypothetical protein	-
IAR31_RS00865 (159187)	159187..159534	+	348	WP_001555786.1	DUF1493 family protein	-
IAR31_RS00870 (159807)	159807..160133	-	327	WP_000393295.1	hypothetical protein	-
IAR31_RS00875 (160727)	160727..161017	+	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
IAR31_RS00880 (161014)	161014..161541	+	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
IAR31_RS00885 (161614)	161614..162032	-	419	Protein_171	transposase	-
IAR31_RS00890 (162265)	162265..162921	+	657	WP_023181885.1	protein-serine/threonine phosphatase	-
IAR31_RS00895 (163093)	163093..163587	-	495	WP_020899151.1	hypothetical protein	-
IAR31_RS00900 (163614)	163614..164282	-	669	WP_000445914.1	hypothetical protein	-
IAR31_RS00905 (164439)	164439..164678	-	240	Protein_175	hypothetical protein	-
IAR31_RS00910 (164869)	164869..165267	-	399	Protein_176	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	161614..161790	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T171157 WP_000971651.1 NZ_CP060849:161014-161541 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T171157 NZ_CP077855:2757200-2757466 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT171157 WP_000855694.1 NZ_CP060849:160727-161017 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT171157 NZ_CP077855:2756949-2757200 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7