Detailed information of TA system TA171154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4035092..4035608
• Replicon: chromosome
• Accession: NZ_CP060846
• Organism: Salmonella enterica strain 733

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAR32_RS19385
• Protein ID: WP_133323120.1
• Coordinates: 4035092..4035376 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAR32_RS19390
• Protein ID: WP_000212724.1
• Coordinates: 4035366..4035608 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR32_RS19370 (4030304)	4030304..4031956	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
IAR32_RS19375 (4032365)	4032365..4034503	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAR32_RS19380 (4034624)	4034624..4035088	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAR32_RS19385 (4035092)	4035092..4035376	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR32_RS19390 (4035366)	4035366..4035608	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAR32_RS19395 (4035686)	4035686..4037599	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAR32_RS19400 (4037616)	4037616..4038356	-	741	WP_023229489.1	KDGP aldolase family protein	-
IAR32_RS19405 (4038353)	4038353..4039471	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAR32_RS19410 (4039455)	4039455..4040588	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171154 WP_133323120.1 NZ_CP060846:c4035376-4035092 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171154 NZ_CP077855:1607301-1607489 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171154 WP_000212724.1 NZ_CP060846:c4035608-4035366 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171154 NZ_CP077855:1607012-1607272 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5