Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3342114..3342734 Replicon chromosome
Accession NZ_CP060846
Organism Salmonella enterica strain 733

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR32_RS16210 Protein ID WP_001280991.1
Coordinates 3342516..3342734 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR32_RS16205 Protein ID WP_000344807.1
Coordinates 3342114..3342488 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR32_RS16195 (3337253) 3337253..3338446 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IAR32_RS16200 (3338469) 3338469..3341618 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR32_RS16205 (3342114) 3342114..3342488 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR32_RS16210 (3342516) 3342516..3342734 + 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR32_RS16215 (3342913) 3342913..3343464 + 552 WP_001278793.1 maltose O-acetyltransferase -
IAR32_RS16220 (3343580) 3343580..3344050 + 471 WP_000136183.1 YlaC family protein -
IAR32_RS16225 (3344106) 3344106..3344246 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR32_RS16230 (3344252) 3344252..3344512 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAR32_RS16235 (3344737) 3344737..3346287 + 1551 WP_000213138.1 EAL domain-containing protein -
IAR32_RS16245 (3346518) 3346518..3346907 + 390 WP_000961285.1 MGMT family protein -
IAR32_RS16250 (3346940) 3346940..3347509 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171150 WP_001280991.1 NZ_CP060846:3342516-3342734 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171150 NZ_CP077855:400794-401045 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171150 WP_000344807.1 NZ_CP060846:3342114-3342488 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171150 NZ_CP077855:401035-401217 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References