Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2246005..2246625 Replicon chromosome
Accession NZ_CP060844
Organism Salmonella enterica strain 770

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR33_RS10580 Protein ID WP_001280991.1
Coordinates 2246005..2246223 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR33_RS10585 Protein ID WP_000344807.1
Coordinates 2246251..2246625 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR33_RS10540 (2241230) 2241230..2241799 + 570 WP_000779802.1 YbaY family lipoprotein -
IAR33_RS10545 (2241832) 2241832..2242221 - 390 WP_000961285.1 MGMT family protein -
IAR33_RS10555 (2242452) 2242452..2244002 - 1551 WP_000213138.1 EAL domain-containing protein -
IAR33_RS10560 (2244227) 2244227..2244487 + 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAR33_RS10565 (2244493) 2244493..2244633 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR33_RS10570 (2244689) 2244689..2245159 - 471 WP_000136183.1 YlaC family protein -
IAR33_RS10575 (2245275) 2245275..2245826 - 552 WP_001278793.1 maltose O-acetyltransferase -
IAR33_RS10580 (2246005) 2246005..2246223 - 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR33_RS10585 (2246251) 2246251..2246625 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR33_RS10590 (2247121) 2247121..2250270 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR33_RS10595 (2250293) 2250293..2251486 - 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171129 WP_001280991.1 NZ_CP060844:c2246223-2246005 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171129 NZ_CP077853:2220473-2220580 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171129 WP_000344807.1 NZ_CP060844:c2246625-2246251 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171129 NZ_CP077853:c2220657-2220597 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References