Detailed information of TA system TA171125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1553131..1553647
• Replicon: chromosome
• Accession: NZ_CP060844
• Organism: Salmonella enterica strain 770

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAR33_RS07405
• Protein ID: WP_133323120.1
• Coordinates: 1553363..1553647 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAR33_RS07400
• Protein ID: WP_000212724.1
• Coordinates: 1553131..1553373 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR33_RS07380 (1548151)	1548151..1549284	+	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-
IAR33_RS07385 (1549268)	1549268..1550386	+	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAR33_RS07390 (1550383)	1550383..1551123	+	741	WP_023229489.1	KDGP aldolase family protein	-
IAR33_RS07395 (1551140)	1551140..1553053	+	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAR33_RS07400 (1553131)	1553131..1553373	+	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAR33_RS07405 (1553363)	1553363..1553647	+	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR33_RS07410 (1553651)	1553651..1554115	-	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAR33_RS07415 (1554236)	1554236..1556374	-	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAR33_RS07420 (1556783)	1556783..1558435	-	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171125 WP_133323120.1 NZ_CP060844:1553363-1553647 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171125 NZ_CP077853:17229-17381 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171125 WP_000212724.1 NZ_CP060844:1553131-1553373 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171125 NZ_CP077853:16605-17204 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5