Detailed information of TA system TA171121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 588242..588829
• Replicon: chromosome
• Accession: NZ_CP060844
• Organism: Salmonella enterica strain 770

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: IAR33_RS02875
• Protein ID: WP_133322382.1
• Coordinates: 588242..588595 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: M7SDJ3
• Locus tag: IAR33_RS02880
• Protein ID: WP_001520924.1
• Coordinates: 588608..588829 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR33_RS02855 (583761)	583761..584831	-	1071	WP_001646570.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
IAR33_RS02860 (584833)	584833..585678	-	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
IAR33_RS02865 (585675)	585675..586562	-	888	WP_000094074.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
IAR33_RS02870 (586667)	586667..587983	-	1317	WP_133322384.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
IAR33_RS02875 (588242)	588242..588595	-	354	WP_133322382.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
IAR33_RS02880 (588608)	588608..588829	-	222	WP_001520924.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IAR33_RS02885 (588960)	588960..589673	-	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
IAR33_RS02890 (589675)	589675..590442	-	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
IAR33_RS02895 (590439)	590439..591716	-	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
IAR33_RS02900 (591713)	591713..592639	-	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
IAR33_RS02905 (592699)	592699..593808	-	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	583024..599050	16026

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-109)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13015.16 Da
• Isoelectric Point: 6.7252

>T171121 WP_133322382.1 NZ_CP060844:c588595-588242 [Salmonella enterica]
ISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALFITLLF
LKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 354 bp

>T171121 NZ_CP077852:c582914-582648 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8152.14 Da
• Isoelectric Point: 5.0775

>AT171121 WP_001520924.1 NZ_CP060844:c588829-588608 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT171121 NZ_CP077852:c583171-582914 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A6C6Z871