Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 63086..63746 Replicon chromosome
Accession NZ_CP060844
Organism Salmonella enterica strain 770

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag IAR33_RS00270 Protein ID WP_000244757.1
Coordinates 63086..63499 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag IAR33_RS00275 Protein ID WP_000351186.1
Coordinates 63480..63746 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR33_RS00250 (59027) 59027..60760 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
IAR33_RS00255 (60766) 60766..61479 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IAR33_RS00260 (61503) 61503..62399 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
IAR33_RS00265 (62512) 62512..63033 + 522 WP_001055885.1 flavodoxin FldB -
IAR33_RS00270 (63086) 63086..63499 - 414 WP_000244757.1 protein YgfX Toxin
IAR33_RS00275 (63480) 63480..63746 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
IAR33_RS00280 (63996) 63996..64976 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
IAR33_RS00285 (65092) 65092..65751 - 660 WP_000250289.1 hemolysin III family protein -
IAR33_RS00290 (65915) 65915..66226 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
IAR33_RS00295 (66385) 66385..67818 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T171120 WP_000244757.1 NZ_CP060844:c63499-63086 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T171120 NZ_CP077852:c551630-551523 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT171120 WP_000351186.1 NZ_CP060844:c63746-63480 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT171120 NZ_CP077852:551446-551506 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References