Detailed information of TA system TA171117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4004213..4004729
• Replicon: chromosome
• Accession: NZ_CP060840
• Organism: Salmonella enterica strain 805

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAR34_RS19150
• Protein ID: WP_133323120.1
• Coordinates: 4004213..4004497 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAR34_RS19155
• Protein ID: WP_000212724.1
• Coordinates: 4004487..4004729 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR34_RS19135 (3999425)	3999425..4001077	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
IAR34_RS19140 (4001486)	4001486..4003624	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAR34_RS19145 (4003745)	4003745..4004209	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAR34_RS19150 (4004213)	4004213..4004497	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR34_RS19155 (4004487)	4004487..4004729	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAR34_RS19160 (4004807)	4004807..4006720	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAR34_RS19165 (4006737)	4006737..4007477	-	741	WP_023229489.1	KDGP aldolase family protein	-
IAR34_RS19170 (4007474)	4007474..4008592	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAR34_RS19175 (4008576)	4008576..4009709	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171117 WP_133323120.1 NZ_CP060840:c4004497-4004213 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171117 NZ_CP077852:c207913-207704 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171117 WP_000212724.1 NZ_CP060840:c4004729-4004487 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171117 NZ_CP077852:c208218-207925 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5