Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3311237..3311857 Replicon chromosome
Accession NZ_CP060840
Organism Salmonella enterica strain 805

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR34_RS15975 Protein ID WP_001280991.1
Coordinates 3311639..3311857 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR34_RS15970 Protein ID WP_000344807.1
Coordinates 3311237..3311611 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR34_RS15960 (3306376) 3306376..3307569 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IAR34_RS15965 (3307592) 3307592..3310741 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR34_RS15970 (3311237) 3311237..3311611 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR34_RS15975 (3311639) 3311639..3311857 + 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR34_RS15980 (3312036) 3312036..3312587 + 552 WP_001278793.1 maltose O-acetyltransferase -
IAR34_RS15985 (3312703) 3312703..3313173 + 471 WP_000136183.1 YlaC family protein -
IAR34_RS15990 (3313229) 3313229..3313369 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR34_RS15995 (3313375) 3313375..3313635 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAR34_RS16000 (3313860) 3313860..3315410 + 1551 WP_000213138.1 EAL domain-containing protein -
IAR34_RS16010 (3315641) 3315641..3316030 + 390 WP_000961285.1 MGMT family protein -
IAR34_RS16015 (3316063) 3316063..3316632 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171113 WP_001280991.1 NZ_CP060840:3311639-3311857 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171113 NZ_CP077850:c3507324-3507004 [Erwinia amylovora]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCTCCCGTGCAGGTGTGGCAGCAACTTTTAAC
GTATCTGCTGGAGCATCATTACGGCTTGACACTAAATGACACGCCATTCCATGACGACGCGGCCATTGAGGAGCATATCG
ACGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGTATCGACCGCAAAGGATTT
ACATGGCAGGAGCAGACGCCATTCCTGGCCGCCACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATATTTA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171113 WP_000344807.1 NZ_CP060840:3311237-3311611 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171113 NZ_CP077850:c3507684-3507361 [Erwinia amylovora]
ATGTCAATCACACTACCTCATGAATGGGGTCTACAAAGCGATATCACCCCACGATTTGGCGCGAGATTAGTTCAGGAAGG
CAATCGGCTGTATTACCTGGCTGACAGGGCTGGATTAACGGTGAGCTTTAGCCCGATACACCTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTGTAGAACAACTGGAAAATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACATCAGGTGACC
ATTCAACTTACGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCAACCCC
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References