Detailed information of TA system TA171098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4047718..4048234
• Replicon: chromosome
• Accession: NZ_CP060837
• Organism: Salmonella enterica strain 852

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAR35_RS19460
• Protein ID: WP_133323120.1
• Coordinates: 4047718..4048002 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAR35_RS19465
• Protein ID: WP_000212724.1
• Coordinates: 4047992..4048234 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR35_RS19445 (4042930)	4042930..4044582	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
IAR35_RS19450 (4044991)	4044991..4047129	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAR35_RS19455 (4047250)	4047250..4047714	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAR35_RS19460 (4047718)	4047718..4048002	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR35_RS19465 (4047992)	4047992..4048234	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAR35_RS19470 (4048312)	4048312..4050225	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAR35_RS19475 (4050242)	4050242..4050982	-	741	WP_023229489.1	KDGP aldolase family protein	-
IAR35_RS19480 (4050979)	4050979..4052097	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAR35_RS19485 (4052081)	4052081..4053214	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171098 WP_133323120.1 NZ_CP060837:c4048002-4047718 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171098 NZ_CP077841:c24919-24560 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171098 WP_000212724.1 NZ_CP060837:c4048234-4047992 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171098 NZ_CP077841:c24560-24261 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5