Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3354740..3355360 Replicon chromosome
Accession NZ_CP060837
Organism Salmonella enterica strain 852

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR35_RS16285 Protein ID WP_001280991.1
Coordinates 3355142..3355360 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR35_RS16280 Protein ID WP_000344807.1
Coordinates 3354740..3355114 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR35_RS16270 (3349879) 3349879..3351072 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IAR35_RS16275 (3351095) 3351095..3354244 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR35_RS16280 (3354740) 3354740..3355114 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR35_RS16285 (3355142) 3355142..3355360 + 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR35_RS16290 (3355539) 3355539..3356090 + 552 WP_001278793.1 maltose O-acetyltransferase -
IAR35_RS16295 (3356206) 3356206..3356676 + 471 WP_000136183.1 YlaC family protein -
IAR35_RS16300 (3356732) 3356732..3356872 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR35_RS16305 (3356878) 3356878..3357138 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAR35_RS16310 (3357363) 3357363..3358913 + 1551 WP_000213138.1 EAL domain-containing protein -
IAR35_RS16320 (3359144) 3359144..3359533 + 390 WP_000961285.1 MGMT family protein -
IAR35_RS16325 (3359566) 3359566..3360135 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171094 WP_001280991.1 NZ_CP060837:3355142-3355360 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171094 NZ_CP077838:c26383-26024 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171094 WP_000344807.1 NZ_CP060837:3354740-3355114 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171094 NZ_CP077838:c26024-25725 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References