Detailed information of TA system TA171085

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1038840..1039654
• Replicon: chromosome
• Accession: NZ_CP060837
• Organism: Salmonella enterica strain 852

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: IAR35_RS05015
• Protein ID: WP_000971651.1
• Coordinates: 1038840..1039367 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: IAR35_RS05020
• Protein ID: WP_000855694.1
• Coordinates: 1039364..1039654 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR35_RS04985 (1035114)	1035114..1035512	+	399	Protein_979	cytoplasmic protein	-
IAR35_RS04990 (1035703)	1035703..1035942	+	240	Protein_980	hypothetical protein	-
IAR35_RS04995 (1036099)	1036099..1036767	+	669	WP_000445914.1	hypothetical protein	-
IAR35_RS05000 (1036794)	1036794..1037288	+	495	WP_020899151.1	hypothetical protein	-
IAR35_RS05005 (1037460)	1037460..1038116	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
IAR35_RS05010 (1038349)	1038349..1038767	+	419	Protein_984	transposase	-
IAR35_RS05015 (1038840)	1038840..1039367	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
IAR35_RS05020 (1039364)	1039364..1039654	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
IAR35_RS05025 (1040248)	1040248..1040574	+	327	WP_000393295.1	hypothetical protein	-
IAR35_RS05030 (1040847)	1040847..1041194	-	348	WP_001555786.1	DUF1493 family protein	-
IAR35_RS05035 (1041179)	1041179..1041628	-	450	WP_133322517.1	hypothetical protein	-
IAR35_RS05040 (1042060)	1042060..1042503	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
IAR35_RS05045 (1042960)	1042960..1043610	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1037460..1048923	11463
	-	flank	IS/Tn	-	-	1038591..1038767	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T171085 WP_000971651.1 NZ_CP060837:c1039367-1038840 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T171085 NZ_CP077831:c7678-7391 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT171085 WP_000855694.1 NZ_CP060837:c1039654-1039364 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT171085 NZ_CP077831:c7404-7090 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7