Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872534..873194 Replicon chromosome
Accession NZ_CP060837
Organism Salmonella enterica strain 852

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag IAR35_RS04270 Protein ID WP_000244757.1
Coordinates 872781..873194 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag IAR35_RS04265 Protein ID WP_000351186.1
Coordinates 872534..872800 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR35_RS04245 (868462) 868462..869895 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
IAR35_RS04250 (870054) 870054..870365 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
IAR35_RS04255 (870529) 870529..871188 + 660 WP_000250289.1 hemolysin III family protein -
IAR35_RS04260 (871304) 871304..872284 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
IAR35_RS04265 (872534) 872534..872800 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
IAR35_RS04270 (872781) 872781..873194 + 414 WP_000244757.1 protein YgfX Toxin
IAR35_RS04275 (873247) 873247..873768 - 522 WP_001055885.1 flavodoxin FldB -
IAR35_RS04280 (873881) 873881..874777 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
IAR35_RS04285 (874801) 874801..875514 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IAR35_RS04290 (875520) 875520..877253 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T171084 WP_000244757.1 NZ_CP060837:872781-873194 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T171084 NZ_CP077831:2606-2962 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT171084 WP_000351186.1 NZ_CP060837:872534-872800 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT171084 NZ_CP077831:2955-3257 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References