Detailed information of TA system TA171079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4036230..4036746
• Replicon: chromosome
• Accession: NZ_CP060834
• Organism: Salmonella enterica strain 1505

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAR36_RS19395
• Protein ID: WP_133323120.1
• Coordinates: 4036230..4036514 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: IAR36_RS19400
• Protein ID: WP_000212724.1
• Coordinates: 4036504..4036746 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR36_RS19380 (4031442)	4031442..4033094	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
IAR36_RS19385 (4033503)	4033503..4035641	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
IAR36_RS19390 (4035762)	4035762..4036226	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAR36_RS19395 (4036230)	4036230..4036514	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR36_RS19400 (4036504)	4036504..4036746	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAR36_RS19405 (4036824)	4036824..4038737	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
IAR36_RS19410 (4038754)	4038754..4039494	-	741	WP_023229489.1	KDGP aldolase family protein	-
IAR36_RS19415 (4039491)	4039491..4040609	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
IAR36_RS19420 (4040593)	4040593..4041726	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T171079 WP_133323120.1 NZ_CP060834:c4036514-4036230 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T171079 NZ_CP077828:460651-461040 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT171079 WP_000212724.1 NZ_CP060834:c4036746-4036504 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT171079 NZ_CP077828:460387-460644 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5