Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3343252..3343872 Replicon chromosome
Accession NZ_CP060834
Organism Salmonella enterica strain 1505

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR36_RS16220 Protein ID WP_001280991.1
Coordinates 3343654..3343872 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR36_RS16215 Protein ID WP_000344807.1
Coordinates 3343252..3343626 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR36_RS16205 (3338391) 3338391..3339584 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IAR36_RS16210 (3339607) 3339607..3342756 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR36_RS16215 (3343252) 3343252..3343626 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR36_RS16220 (3343654) 3343654..3343872 + 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR36_RS16225 (3344051) 3344051..3344602 + 552 WP_001278793.1 maltose O-acetyltransferase -
IAR36_RS16230 (3344718) 3344718..3345188 + 471 WP_000136183.1 YlaC family protein -
IAR36_RS16235 (3345244) 3345244..3345384 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR36_RS16240 (3345390) 3345390..3345650 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
IAR36_RS16245 (3345875) 3345875..3347425 + 1551 WP_000213138.1 EAL domain-containing protein -
IAR36_RS16255 (3347656) 3347656..3348045 + 390 WP_000961285.1 MGMT family protein -
IAR36_RS16260 (3348078) 3348078..3348647 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171075 WP_001280991.1 NZ_CP060834:3343654-3343872 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171075 NZ_CP077824:c4313340-4312930 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171075 WP_000344807.1 NZ_CP060834:3343252-3343626 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171075 NZ_CP077824:c4313587-4313321 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References