Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3529488..3530105 Replicon chromosome
Accession NZ_CP060818
Organism Pantoea ananatis strain Lstri

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag IAQ00_RS16810 Protein ID WP_028723979.1
Coordinates 3529890..3530105 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag IAQ00_RS16805 Protein ID WP_028723978.1
Coordinates 3529488..3529865 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ00_RS16775 (IAQ00_16700) 3525774..3526028 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
IAQ00_RS16780 (IAQ00_16705) 3526040..3526180 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
IAQ00_RS16785 (IAQ00_16710) 3526240..3527118 - 879 WP_047714454.1 metal ABC transporter substrate-binding protein -
IAQ00_RS16790 (IAQ00_16715) 3527131..3527970 - 840 WP_047714453.1 metal ABC transporter permease -
IAQ00_RS16795 (IAQ00_16720) 3527967..3528635 - 669 WP_252293507.1 ATP-binding cassette domain-containing protein -
IAQ00_RS16800 (IAQ00_16725) 3528988..3529341 + 354 WP_028723977.1 hypothetical protein -
IAQ00_RS16805 (IAQ00_16730) 3529488..3529865 + 378 WP_028723978.1 Hha toxicity modulator TomB Antitoxin
IAQ00_RS16810 (IAQ00_16735) 3529890..3530105 + 216 WP_028723979.1 HHA domain-containing protein Toxin
IAQ00_RS16820 (IAQ00_16745) 3530503..3530814 + 312 WP_028723980.1 MGMT family protein -
IAQ00_RS16825 (IAQ00_16750) 3530863..3531420 - 558 WP_064365624.1 YbaY family lipoprotein -
IAQ00_RS16830 (IAQ00_16755) 3531613..3532476 + 864 WP_064365625.1 acyl-CoA thioesterase II -
IAQ00_RS16835 (IAQ00_16760) 3532523..3533812 - 1290 WP_028723982.1 ammonium transporter AmtB -
IAQ00_RS16840 (IAQ00_16765) 3533847..3534185 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8542.94 Da        Isoelectric Point: 9.4825

>T171058 WP_028723979.1 NZ_CP060818:3529890-3530105 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T171058 NZ_CP077823:1761153-1761485 [Klebsiella africana]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14709.35 Da        Isoelectric Point: 4.4069

>AT171058 WP_028723978.1 NZ_CP060818:3529488-3529865 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCESLFDESMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT171058 NZ_CP077823:1760895-1761152 [Klebsiella africana]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References