Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 841456..842108 Replicon chromosome
Accession NZ_CP060818
Organism Pantoea ananatis strain Lstri

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag IAQ00_RS04070 Protein ID WP_033778077.1
Coordinates 841710..842108 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag IAQ00_RS04065 Protein ID WP_028724117.1
Coordinates 841456..841686 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ00_RS04050 (IAQ00_04035) 837416..838624 + 1209 WP_081046452.1 conjugal transfer protein TraF -
IAQ00_RS04055 (IAQ00_04040) 838678..839232 + 555 WP_064366690.1 hypothetical protein -
IAQ00_RS04060 (IAQ00_04045) 839710..840868 - 1159 Protein_789 IS30 family transposase -
IAQ00_RS04065 (IAQ00_04050) 841456..841686 + 231 WP_028724117.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IAQ00_RS04070 (IAQ00_04055) 841710..842108 + 399 WP_033778077.1 type II toxin-antitoxin system VapC family toxin Toxin
IAQ00_RS04075 (IAQ00_04060) 842335..843210 - 876 WP_252294280.1 N-acetylmuramoyl-L-alanine amidase -
IAQ00_RS04080 (IAQ00_04065) 843240..843521 - 282 WP_028724120.1 LuxR C-terminal-related transcriptional regulator -
IAQ00_RS04085 (IAQ00_04070) 843930..844487 + 558 WP_252294282.1 fimbrial protein -
IAQ00_RS04090 (IAQ00_04075) 844550..845221 + 672 WP_221611350.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 840269..883098 42829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14290.62 Da        Isoelectric Point: 7.2161

>T171049 WP_033778077.1 NZ_CP060818:841710-842108 [Pantoea ananatis]
MLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYAEMRFGASGPKASPRHVQLVDAFCARLDAVLPWDRAAVDAT
TEIKVSLRLAGTPIGPNDTAIAGHAITVGAILVTNNVREFARVPGLALEDWV

Download         Length: 399 bp

>T171049 NZ_CP077820:c1123566-1123348 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8702.83 Da        Isoelectric Point: 4.6158

>AT171049 WP_028724117.1 NZ_CP060818:841456-841686 [Pantoea ananatis]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFLELEKADPHFMAERGDVVSDEGRFDL

Download         Length: 231 bp

>AT171049 NZ_CP077820:c1123967-1123593 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References