Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 128288..128816 | Replicon | plasmid pXM9F202-2-186k |
| Accession | NZ_CP060812 | ||
| Organism | Acinetobacter variabilis strain XM9F202-2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | N9N871 |
| Locus tag | IAQ69_RS15860 | Protein ID | WP_000221358.1 |
| Coordinates | 128523..128816 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | IAQ69_RS15855 | Protein ID | WP_166138376.1 |
| Coordinates | 128288..128533 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IAQ69_RS15805 | 123391..123711 | - | 321 | WP_004755868.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IAQ69_RS15810 | 123858..124589 | - | 732 | WP_166138371.1 | EcsC family protein | - |
| IAQ69_RS15815 | 124771..125067 | + | 297 | WP_005175534.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IAQ69_RS15820 | 125069..125359 | + | 291 | WP_060875721.1 | putative addiction module antidote protein | - |
| IAQ69_RS15825 | 125446..125790 | - | 345 | WP_004282115.1 | hypothetical protein | - |
| IAQ69_RS15830 | 125802..126068 | - | 267 | WP_004282113.1 | DUF4258 domain-containing protein | - |
| IAQ69_RS15835 | 126235..126717 | + | 483 | WP_166138373.1 | hypothetical protein | - |
| IAQ69_RS15840 | 126710..127021 | + | 312 | WP_004282111.1 | hypothetical protein | - |
| IAQ69_RS15845 | 127162..127551 | - | 390 | WP_121594982.1 | tautomerase family protein | - |
| IAQ69_RS15850 | 127815..128186 | + | 372 | WP_004726814.1 | hypothetical protein | - |
| IAQ69_RS15855 | 128288..128533 | + | 246 | WP_166138376.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| IAQ69_RS15860 | 128523..128816 | + | 294 | WP_000221358.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IAQ69_RS15865 | 129000..129737 | + | 738 | WP_200230931.1 | hypothetical protein | - |
| IAQ69_RS15870 | 129892..130380 | + | 489 | WP_166138379.1 | hypothetical protein | - |
| IAQ69_RS15875 | 130610..132235 | - | 1626 | WP_200230908.1 | IS66 family transposase | - |
| IAQ69_RS15880 | 132310..132645 | - | 336 | WP_200230705.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| IAQ69_RS15885 | 132642..133025 | - | 384 | WP_166135939.1 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) / sul2 / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aac(3)-IId / msr(E) / mph(E) / floR | - | 1..186242 | 186242 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11292.52 Da Isoelectric Point: 10.4753
>T171042 WP_000221358.1 NZ_CP060812:128523-128816 [Acinetobacter variabilis]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T171042 NZ_CP077818:3191538-3191855 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9163.55 Da Isoelectric Point: 4.3895
>AT171042 WP_166138376.1 NZ_CP060812:128288-128533 [Acinetobacter variabilis]
MATVNFRVDGALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
MATVNFRVDGALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT171042 NZ_CP077818:3191848-3192135 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|