171041

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 124771..125359 Replicon plasmid pXM9F202-2-186k
Accession NZ_CP060812
Organism Acinetobacter variabilis strain XM9F202-2

Toxin (Protein)


Gene name relE Uniprot ID N9MLD7
Locus tag IAQ69_RS15815 Protein ID WP_005175534.1
Coordinates 124771..125067 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2S4T219
Locus tag IAQ69_RS15820 Protein ID WP_060875721.1
Coordinates 125069..125359 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ69_RS15780 119826..120855 - 1030 Protein_118 IS3 family transposase -
IAQ69_RS15785 121038..121604 - 567 WP_006581699.1 recombinase family protein -
IAQ69_RS15790 121923..122075 + 153 Protein_120 monooxygenase -
IAQ69_RS15795 122312..123016 - 705 WP_180058100.1 IS6 family transposase -
IAQ69_RS15800 123126..123398 - 273 WP_004896911.1 helix-turn-helix domain-containing protein -
IAQ69_RS15805 123391..123711 - 321 WP_004755868.1 type II toxin-antitoxin system RelE/ParE family toxin -
IAQ69_RS15810 123858..124589 - 732 WP_166138371.1 EcsC family protein -
IAQ69_RS15815 124771..125067 + 297 WP_005175534.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAQ69_RS15820 125069..125359 + 291 WP_060875721.1 putative addiction module antidote protein Antitoxin
IAQ69_RS15825 125446..125790 - 345 WP_004282115.1 hypothetical protein -
IAQ69_RS15830 125802..126068 - 267 WP_004282113.1 DUF4258 domain-containing protein -
IAQ69_RS15835 126235..126717 + 483 WP_166138373.1 hypothetical protein -
IAQ69_RS15840 126710..127021 + 312 WP_004282111.1 hypothetical protein -
IAQ69_RS15845 127162..127551 - 390 WP_121594982.1 tautomerase family protein -
IAQ69_RS15850 127815..128186 + 372 WP_004726814.1 hypothetical protein -
IAQ69_RS15855 128288..128533 + 246 WP_166138376.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IAQ69_RS15860 128523..128816 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin -
IAQ69_RS15865 129000..129737 + 738 WP_200230931.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(M) / sul2 / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aac(3)-IId / msr(E) / mph(E) / floR - 1..186242 186242
- inside IScluster/Tn aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aac(3)-IId / msr(E) / mph(E) / floR - 87389..123016 35627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11568.25 Da        Isoelectric Point: 5.8801

>T171041 WP_005175534.1 NZ_CP060812:124771-125067 [Acinetobacter variabilis]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T171041 NZ_CP077818:c3065327-3065109 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATTCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10519.17 Da        Isoelectric Point: 5.6088

>AT171041 WP_060875721.1 NZ_CP060812:125069-125359 [Acinetobacter variabilis]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEDNDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRHDSAPRFDTI
NRVVNALGLKLTVQHA

Download         Length: 291 bp

>AT171041 NZ_CP077818:c3065728-3065354 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9MLD7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4T219

References