Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2397220..2397729 Replicon chromosome
Accession NZ_CP060794
Organism Staphylococcus epidermidis strain Z0118SE0260

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag H9Q14_RS11510 Protein ID WP_001829980.1
Coordinates 2397220..2397429 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag H9Q14_RS11515 Protein ID WP_001829893.1
Coordinates 2397436..2397729 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q14_RS11490 2392798..2394153 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
H9Q14_RS11495 2394165..2395238 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
H9Q14_RS11500 2395629..2396840 + 1212 WP_001829910.1 rod shape-determining protein RodA -
H9Q14_RS11505 2396940..2397077 - 138 WP_001829949.1 hypothetical protein -
H9Q14_RS11510 2397220..2397429 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
H9Q14_RS11515 2397436..2397729 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
H9Q14_RS11520 2397903..2399387 + 1485 WP_002457116.1 cardiolipin synthase -
H9Q14_RS11525 2399569..2400222 + 654 WP_001829983.1 HD domain-containing protein -
H9Q14_RS11530 2400328..2401200 - 873 WP_002458703.1 membrane protein insertase YidC -
H9Q14_RS11535 2401289..2401927 - 639 WP_002505076.1 thiamine phosphate synthase -
H9Q14_RS11540 2401933..2402721 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T170972 WP_001829980.1 NZ_CP060794:c2397429-2397220 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T170972 NZ_CP077809:595867-596208 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATATCTGTCCCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT170972 WP_001829893.1 NZ_CP060794:c2397729-2397436 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT170972 NZ_CP077809:595520-595846 [Klebsiella pneumoniae]
ATGTCATCAAATGACTTACAGCAATGGGGATTATGTCGCAGCATCTCACCGTGCTTTGGCGCAAGGCTCGTACAGGAGAG
AAACCGCCTGCACTTTCTAGCTGACCGCGCCGGTTTTAACGGTCAGTTTACCGAAGAGCAGGCGCTGCGACTCGATCAGG
CATTTCCTCTGATTATGAAGCAACTCGAGCTTATGCTCTCCACCGGTGAGCTAAATCCGCGCCACTCGCATTGTGTCACC
CTTTACCACAATGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCA
TCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References