Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2386016..2386545 Replicon chromosome
Accession NZ_CP060794
Organism Staphylococcus epidermidis strain Z0118SE0260

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag H9Q14_RS11450 Protein ID WP_001829891.1
Coordinates 2386016..2386378 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag H9Q14_RS11455 Protein ID WP_001829931.1
Coordinates 2386375..2386545 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q14_RS11430 2383017..2383787 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
H9Q14_RS11435 2383762..2384241 - 480 WP_001829903.1 anti-sigma B factor RsbW -
H9Q14_RS11440 2384243..2384569 - 327 WP_001829952.1 anti-sigma factor antagonist -
H9Q14_RS11445 2384669..2385670 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
H9Q14_RS11450 2386016..2386378 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H9Q14_RS11455 2386375..2386545 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
H9Q14_RS11460 2386632..2387780 - 1149 WP_002468951.1 alanine racemase -
H9Q14_RS11465 2387846..2388199 - 354 WP_001829915.1 holo-ACP synthase -
H9Q14_RS11470 2388247..2388757 - 511 Protein_2218 PH domain-containing protein -
H9Q14_RS11475 2388744..2390249 - 1506 WP_001829976.1 PH domain-containing protein -
H9Q14_RS11480 2390242..2390721 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T170971 WP_001829891.1 NZ_CP060794:c2386378-2386016 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T170971 NZ_CP077809:506760-507044 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT170971 WP_001829931.1 NZ_CP060794:c2386545-2386375 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT170971 NZ_CP077809:506528-506770 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References