Detailed information of TA system TA170969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1214820..1216099
• Replicon: chromosome
• Accession: NZ_CP060790
• Organism: Acidovorax monticola strain KACC 19171

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H9L24_RS05725
• Protein ID: WP_187737342.1
• Coordinates: 1215515..1216099 (+)
• Length: 195 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H9L24_RS05720
• Protein ID: WP_187737341.1
• Coordinates: 1214820..1215410 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L24_RS05695	1210306..1210524	+	219	WP_187737338.1	DUF1059 domain-containing protein	-
H9L24_RS05700	1210586..1211776	-	1191	WP_187737339.1	YeeE/YedE family protein	-
H9L24_RS05705	1211891..1212844	-	954	WP_187737340.1	sulfurtransferase	-
H9L24_RS05710	1213098..1214443	+	1346	Protein_1117	carbohydrate porin	-
H9L24_RS05720	1214820..1215410	+	591	WP_187737341.1	helix-turn-helix transcriptional regulator	Antitoxin
H9L24_RS05725	1215515..1216099	+	585	WP_187737342.1	HD domain-containing protein	Toxin
H9L24_RS05730	1216088..1217020	-	933	WP_187737343.1	GlxA family transcriptional regulator	-
H9L24_RS05735	1217120..1218361	+	1242	WP_187737344.1	MFS transporter	-
H9L24_RS05740	1218484..1219392	-	909	WP_187737345.1	LysR family transcriptional regulator	-
H9L24_RS05745	1219516..1220517	+	1002	WP_187737346.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-166)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-74)

Sequences

Toxin

Protein

• Length: 195 a.a.
• Molecular weight: 21428.41 Da
• Isoelectric Point: 6.4894

>T170969 WP_187737342.1 NZ_CP060790:1215515-1216099 [Acidovorax monticola]
MDGALVDGRLNFLRACERLKDVLRSGHTSTGRRESTAEHSWRLGLMAMVFMDQLGDIDRARVLELCLVHDLGEALGGDVP
APQQPAGGSKDATERRDLLKICETLDPAMREKIVGLWDEYAQAATPEARAVKALDKLETILQHTQGANPPGFDYAFNLAY
GQKYTKALPVLEVLRGRIDNATRARMARPDGSRE

Nucleotide

• Length: 585 bp

>T170969 NZ_CP077808:c124864-124448 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGTCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGTGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCTATCGCCACCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 21783.85 Da
• Isoelectric Point: 8.5325

>AT170969 WP_187737341.1 NZ_CP060790:1214820-1215410 [Acidovorax monticola]
MKQIPTVDAAVSPAARSGLPYSPGAMLRRWRMLRRIKQEHAAQLFGVSQSTVSRWESGIQSVSRDELVRIEGFFAARLDS
AADYALERLVSHSTQPVHLVCDLTHRLLACSSPRAAEFASPLPELMGRSLWPFATAEIVAREQSLRDAGWHDHATPSIEF
DTGCNTSAQVPIRMSRCRWTRLTLSDGTVARLVETL

Nucleotide

• Length: 591 bp

>AT170969 NZ_CP077808:c125091-124861 [Klebsiella pneumoniae]
ATGCGTACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA