Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3325786..3326337 Replicon chromosome
Accession NZ_CP060789
Organism Tessaracoccus defluvii strain JCM 17540

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H9L22_RS15725 Protein ID WP_187720726.1
Coordinates 3325786..3326100 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H9L22_RS15730 Protein ID WP_187720727.1
Coordinates 3326104..3326337 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L22_RS15690 3321232..3322397 + 1166 WP_182784986.1 IS3 family transposase -
H9L22_RS15695 3322564..3322827 - 264 WP_187722780.1 hypothetical protein -
H9L22_RS15700 3323301..3323573 + 273 WP_187720721.1 TetR/AcrR family transcriptional regulator -
H9L22_RS15705 3323578..3323883 + 306 WP_187720722.1 hypothetical protein -
H9L22_RS15710 3323980..3324291 - 312 WP_187720723.1 hypothetical protein -
H9L22_RS15715 3324278..3324568 - 291 WP_187720724.1 hypothetical protein -
H9L22_RS15720 3324831..3325508 - 678 WP_187720725.1 hemolysin III family protein -
H9L22_RS15725 3325786..3326100 - 315 WP_187720726.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H9L22_RS15730 3326104..3326337 - 234 WP_187720727.1 ribbon-helix-helix protein, CopG family Antitoxin
H9L22_RS15735 3326459..3329574 + 3116 Protein_3098 type I restriction endonuclease subunit R -
H9L22_RS15740 3329587..3330834 - 1248 WP_187722733.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11038.85 Da        Isoelectric Point: 6.4567

>T170968 WP_187720726.1 NZ_CP060789:c3326100-3325786 [Tessaracoccus defluvii]
VREICLVRLDKTRPAVVLTREAARAAMTKVTIAPITSTVKGLSSEVPVGPANGLDHDGVISLDNVVTVPSRLLGRTVGFL
THAQEAELARAVVLAYDLDIPLLD

Download         Length: 315 bp

>T170968 NZ_CP077806:4799725-4800135 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8464.51 Da        Isoelectric Point: 4.3055

>AT170968 WP_187720727.1 NZ_CP060789:c3326337-3326104 [Tessaracoccus defluvii]
MSTQIAIRLPDDMVAFLDKSVAAGDAPSRAALVARAVEREMRRQVAEQDAVILRERGTADDLDELVNWSVAHTTVED

Download         Length: 234 bp

>AT170968 NZ_CP077806:4799478-4799744 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References