Detailed information of TA system TA170967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 2905143..2905795
• Replicon: chromosome
• Accession: NZ_CP060789
• Organism: Tessaracoccus defluvii strain JCM 17540

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H9L22_RS13800
• Protein ID: WP_187720428.1
• Coordinates: 2905143..2905538 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H9L22_RS13805
• Protein ID: WP_187720429.1
• Coordinates: 2905535..2905795 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L22_RS13780	2900565..2900765	+	201	Protein_2709	HIT domain-containing protein	-
H9L22_RS13785	2900698..2901714	+	1017	WP_187720425.1	exodeoxyribonuclease III	-
H9L22_RS13790	2901740..2902342	-	603	WP_187720426.1	TetR/AcrR family transcriptional regulator	-
H9L22_RS13795	2902347..2904863	-	2517	WP_187720427.1	MMPL family transporter	-
H9L22_RS13800	2905143..2905538	-	396	WP_187720428.1	type II toxin-antitoxin system VapC family toxin	Toxin
H9L22_RS13805	2905535..2905795	-	261	WP_187720429.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H9L22_RS13810	2905907..2907722	-	1816	Protein_2715	phosphoenolpyruvate carboxykinase (GTP)	-
H9L22_RS13815	2907855..2909285	+	1431	WP_187720430.1	XRE family transcriptional regulator	-
H9L22_RS13820	2909314..2909742	-	429	WP_187720431.1	PIN domain-containing protein	-
H9L22_RS13825	2909739..2910011	-	273	WP_182799249.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
H9L22_RS13830	2910083..2910406	-	324	WP_187720432.1	DUF4143 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2875875..2995419	119544
	-	flank	IS/Tn	-	-	2910476..2910649	173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-39)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 13638.69 Da
• Isoelectric Point: 4.2457

>T170967 WP_187720428.1 NZ_CP060789:c2905538-2905143 [Tessaracoccus defluvii]
VSAGLLDTSVWIAGEVGRLLDTAALPDEAYVCVVTLAELQAGVLAAPDTRTRVARLATVERLAGLEPLAVDGAVARQWAS
LRVQLHEAGRSMGINDLWIAAVALANGLPVVTQDSGFDVLGELGALEVIRV

Nucleotide

• Length: 396 bp

>T170967 NZ_CP077806:4734438-4734923 [Klebsiella pneumoniae]
ATGATCGCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9374.63 Da
• Isoelectric Point: 7.2050

>AT170967 WP_187720429.1 NZ_CP060789:c2905795-2905535 [Tessaracoccus defluvii]
MSTVASRDLRNHTRSVLDRVAAGDVVTVTVNGEPVAEIRSPTRRRPVAMKRSDLIDLVHAQRVDVTLEADLGWISAGSTE
DLGPIR

Nucleotide

• Length: 261 bp

>AT170967 NZ_CP077806:4734148-4734441 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA