Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2205041..2205570 Replicon chromosome
Accession NZ_CP060789
Organism Tessaracoccus defluvii strain JCM 17540

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H9L22_RS10630 Protein ID WP_187719892.1
Coordinates 2205244..2205570 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H9L22_RS10625 Protein ID WP_187719891.1
Coordinates 2205041..2205247 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L22_RS10595 2201025..2201354 + 330 WP_187719888.1 hypothetical protein -
H9L22_RS10605 2202801..2203151 - 351 Protein_2081 carbohydrate ABC transporter permease -
H9L22_RS10610 2203153..2204226 - 1074 Protein_2082 DEAD/DEAH box helicase family protein -
H9L22_RS10615 2204451..2204594 - 144 WP_187719889.1 hypothetical protein -
H9L22_RS10620 2204603..2204935 - 333 WP_187719890.1 GNAT family N-acetyltransferase -
H9L22_RS10625 2205041..2205247 + 207 WP_187719891.1 antitoxin MazE family protein Antitoxin
H9L22_RS10630 2205244..2205570 + 327 WP_187719892.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H9L22_RS10635 2205665..2206132 + 468 WP_187719893.1 NAD(+)--rifampin ADP-ribosyltransferase -
H9L22_RS10640 2206315..2206845 - 531 WP_187719894.1 GNAT family N-acetyltransferase -
H9L22_RS10645 2207127..2208485 - 1359 WP_187719895.1 GntP family transporter -
H9L22_RS10650 2208489..2209370 - 882 WP_187719896.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(5-65)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11858.91 Da        Isoelectric Point: 11.1986

>T170966 WP_187719892.1 NZ_CP060789:2205244-2205570 [Tessaracoccus defluvii]
MRRAEVWTVAGGISASKPRPAIIVQDDVFELTDSITVAPLTTTLVDAPLLRLRVPAGGLTGLAQDSDVMVDKLTTVRRSN
VQVRIGRLSRQQMVELERLLMTFLGMAR

Download         Length: 327 bp

>T170966 NZ_CP077806:4332001-4332348 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7860.62 Da        Isoelectric Point: 5.0484

>AT170966 WP_187719891.1 NZ_CP060789:2205041-2205247 [Tessaracoccus defluvii]
MAVSDRVGQHRHRMRARGYRPVQIWVPDVRTEQFAREAGHQAALVAQNDREGDDQDFIEAVTVGWDEE

Download         Length: 207 bp

>AT170966 NZ_CP077806:4332348-4332647 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References