Detailed information of TA system TA170965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2176611..2177149
• Replicon: chromosome
• Accession: NZ_CP060789
• Organism: Tessaracoccus defluvii strain JCM 17540

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H9L22_RS10470
• Protein ID: WP_187719865.1
• Coordinates: 2176611..2176886 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H9L22_RS10475
• Protein ID: WP_187719866.1
• Coordinates: 2176883..2177149 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L22_RS10450	2172211..2172792	+	582	Protein_2050	transposase	-
H9L22_RS10455	2173094..2173564	+	471	WP_187719862.1	nucleotidyltransferase domain-containing protein	-
H9L22_RS10460	2173615..2173986	+	372	WP_187719863.1	DUF86 domain-containing protein	-
H9L22_RS10465	2173986..2176367	+	2382	WP_187719864.1	DEAD/DEAH box helicase	-
H9L22_RS10470	2176611..2176886	-	276	WP_187719865.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9L22_RS10475	2176883..2177149	-	267	WP_187719866.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9L22_RS10480	2177520..2180069	+	2550	WP_187719867.1	AAA family ATPase	-
H9L22_RS10485	2180045..2181079	+	1035	WP_187719868.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (38-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10419.02 Da
• Isoelectric Point: 8.5341

>T170965 WP_187719865.1 NZ_CP060789:c2176886-2176611 [Tessaracoccus defluvii]
VSPGANYELVLTPPAIRAIQSELPEAVAAAVIEFMTGPLVENPRRVGKMLRRELEGIWSARRGTYRVLYRINDHVDEVVV
LHIDHRRDVYR

Nucleotide

• Length: 276 bp

>T170965 NZ_CP077806:4305574-4305942 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTTGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9791.85 Da
• Isoelectric Point: 4.4829

>AT170965 WP_187719866.1 NZ_CP060789:c2177149-2176883 [Tessaracoccus defluvii]
MTAESLREVRDHFSEVVDRVELHHERVTVTRNGRPVAVLISPADLAELEETLDVLSDPDALADIREADAAYARGDVARGD
DAIRSLRR

Nucleotide

• Length: 267 bp

>AT170965 NZ_CP077806:4305356-4305577 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA