Detailed information of TA system TA170961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4536176..4536846
• Replicon: chromosome
• Accession: NZ_CP060783
• Organism: Diaphorobacter aerolatus strain KACC 16536

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H9K75_RS21270
• Protein ID: WP_187724041.1
• Coordinates: 4536176..4536595 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H9K75_RS21275
• Protein ID: WP_187726135.1
• Coordinates: 4536592..4536846 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9K75_RS21260	4531911..4533686	-	1776	WP_187724039.1	type I restriction-modification system subunit M	-
H9K75_RS21265	4533722..4536148	-	2427	WP_187724040.1	DEAD/DEAH box helicase family protein	-
H9K75_RS21270	4536176..4536595	-	420	WP_187724041.1	type II toxin-antitoxin system VapC family toxin	Toxin
H9K75_RS21275	4536592..4536846	-	255	WP_187726135.1	Arc family DNA-binding protein	Antitoxin
H9K75_RS21285	4537201..4539106	-	1906	Protein_4184	SurA N-terminal domain-containing protein	-
H9K75_RS21295	4539587..4539859	-	273	WP_043387285.1	HU family DNA-binding protein	-
H9K75_RS21300	4540172..4540741	-	570	WP_187724042.1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14764.23 Da
• Isoelectric Point: 5.8324

>T170961 WP_187724041.1 NZ_CP060783:c4536595-4536176 [Diaphorobacter aerolatus]
MILLDTNVMLEPLRHAPEPRVIEWIDAQAMDTLFLSAITVAELRAGVVLLPAGKRRACLQENLEKRVLPLFAGRVLPFDL
ACTQAYAALMAKARAVGTAISSADAYIAAIASANGFAVATRDTSLFEAAGAGVINPWQG

Nucleotide

• Length: 420 bp

>T170961 NZ_CP077806:c3317110-3316577 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.77 Da
• Isoelectric Point: 5.7268

>AT170961 WP_187726135.1 NZ_CP060783:c4536846-4536592 [Diaphorobacter aerolatus]
MAMLTVRNLPEEVHRALRVRAAQHGQSMEAEVREILESAISPKGRVKLGSLLADMGRQAKLSDEEFAVFEQVRDETPARP
VSFE

Nucleotide

• Length: 255 bp

>AT170961 NZ_CP077806:c3317387-3317121 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA