Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4251259..4252301 Replicon chromosome
Accession NZ_CP060783
Organism Diaphorobacter aerolatus strain KACC 16536

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag H9K75_RS19800 Protein ID WP_003153636.1
Coordinates 4251726..4252301 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag H9K75_RS19795 Protein ID WP_003050245.1
Coordinates 4251259..4251729 (+) Length 157 a.a.

Genomic Context

H9K75_RS19795H9K75_RS19800H9K75_RS19805H9K75_RS19810H9K75_RS19815H9K75_RS19820H9K75_RS19760H9K75_RS19765H9K75_RS19770H9K75_RS19775H9K75_RS19780H9K75_RS19785H9K75_RS19790
Location: 4251259..4251729 (471 bp)
Type: Antitoxin
Protein ID: WP_003050245.1
Location: 4251726..4252301 (576 bp)
Type: Toxin
Protein ID: WP_003153636.1
Location: 4252319..4253233 (915 bp)
Type: Others
Protein ID: WP_003050256.1
Location: 4253230..4253700 (471 bp)
Type: Others
Protein ID: WP_003153638.1
Location: 4253697..4254197 (501 bp)
Type: Others
Protein ID: WP_003090159.1
Location: 4254197..4254796 (600 bp)
Type: Others
Protein ID: Protein_3895
Location: 4246646..4248063 (1418 bp)
Type: Others
Protein ID: Protein_3883
Location: 4248053..4248970 (918 bp)
Type: Others
Protein ID: WP_047219622.1
Location: 4248967..4249659 (693 bp)
Type: Others
Protein ID: WP_004350603.1
Location: 4249656..4250054 (399 bp)
Type: Others
Protein ID: WP_003153632.1
Location: 4250067..4250426 (360 bp)
Type: Others
Protein ID: WP_003153634.1
Location: 4250443..4250676 (234 bp)
Type: Others
Protein ID: WP_003050225.1
Location: 4250673..4251055 (383 bp)
Type: Others
Protein ID: Protein_3889
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H9K75_RS197604246646..4248063-1418Protein_3883TIGR03752 family integrating conjugative element protein-
H9K75_RS197654248053..4248970-918WP_047219622.1TIGR03749 family integrating conjugative element protein-
H9K75_RS197704248967..4249659-693WP_004350603.1TIGR03746 family integrating conjugative element protein-
H9K75_RS197754249656..4250054-399WP_003153632.1TIGR03750 family conjugal transfer protein-
H9K75_RS197804250067..4250426-360WP_003153634.1TIGR03745 family integrating conjugative element membrane protein-
H9K75_RS197854250443..4250676-234WP_003050225.1TIGR03758 family integrating conjugative element protein-
H9K75_RS197904250673..4251055-383Protein_3889RAQPRD family integrative conjugative element protein-
H9K75_RS197954251259..4251729+471WP_003050245.1helix-turn-helix domain-containing proteinAntitoxin
H9K75_RS198004251726..4252301+576WP_003153636.1PIN domain-containing proteinToxin
H9K75_RS198054252319..4253233+915WP_003050256.1AAA family ATPase-
H9K75_RS198104253230..4253700+471WP_003153638.1hypothetical protein-
H9K75_RS198154253697..4254197+501WP_003090159.1hypothetical protein-
H9K75_RS198204254197..4254796+600Protein_3895nucleotidyltransferase domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T170960 WP_003153636.1 NZ_CP060783:4251726-4252301 [Diaphorobacter aerolatus]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T170960 NZ_CP077806:2699900-2700118 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT170960 WP_003050245.1 NZ_CP060783:4251259-4251729 [Diaphorobacter aerolatus]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT170960 NZ_CP077806:2699499-2699873 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBI3TV68

References