Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 983392..983981 Replicon chromosome
Accession NZ_CP060780
Organism Sphingomonas daechungensis strain KACC 18115

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H9L15_RS05170 Protein ID WP_187715412.1
Coordinates 983688..983981 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H9L15_RS05165 Protein ID WP_187715411.1
Coordinates 983392..983688 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L15_RS05145 979039..980061 - 1023 WP_187715409.1 hypothetical protein -
H9L15_RS05150 980290..982093 + 1804 Protein_1018 elongation factor 4 -
H9L15_RS05155 982566..982832 + 267 WP_187715797.1 DNA cytosine methyltransferase -
H9L15_RS05160 982805..983203 - 399 WP_187715410.1 DNA mismatch endonuclease Vsr -
H9L15_RS05165 983392..983688 - 297 WP_187715411.1 putative addiction module antidote protein Antitoxin
H9L15_RS05170 983688..983981 - 294 WP_187715412.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9L15_RS05175 984046..984231 - 186 WP_187715413.1 hypothetical protein -
H9L15_RS05180 984352..985260 - 909 WP_187715414.1 hypothetical protein -
H9L15_RS05185 985399..985716 - 318 WP_187715415.1 PilZ domain-containing protein -
H9L15_RS05190 986237..987532 + 1296 WP_187715416.1 L,D-transpeptidase family protein -
H9L15_RS05195 987769..988140 + 372 WP_187715417.1 hypothetical protein -
H9L15_RS05200 988174..988590 + 417 WP_187715418.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-88)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10726.24 Da        Isoelectric Point: 7.9683

>T170959 WP_187715412.1 NZ_CP060780:c983981-983688 [Sphingomonas daechungensis]
MIEVRQTTRFATWLAGLRDERARARILKRLDRAGQGNLGDVAPVGDGVSEIRIFYGPGYRVYFIQRGSELIVLLCGGDKS
TQSADIEEAKALAKEVD

Download         Length: 294 bp

>T170959 NZ_CP077806:c1341387-1340065 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGATCCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCTCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTTGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACTTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGGCTCACCCCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10475.74 Da        Isoelectric Point: 4.4354

>AT170959 WP_187715411.1 NZ_CP060780:c983688-983392 [Sphingomonas daechungensis]
MAKIETTAFDSADYLNTAETIAAYLDAYLEDSTPEELRTALATVARSHGISDLARRSGISRPGIYKALGQDGNPSFETIR
AILSAMGLRLTVEPAEVG

Download         Length: 297 bp

>AT170959 NZ_CP077806:c1341653-1341387 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAATCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCGACACTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References