Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 51442..51964 Replicon plasmid pEC96-153kb
Accession NZ_CP060749
Organism Escherichia coli strain EC96

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag IAI02_RS21775 Protein ID WP_000220561.1
Coordinates 51683..51964 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag IAI02_RS21770 Protein ID WP_000121743.1
Coordinates 51442..51693 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI02_RS21750 47565..47987 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
IAI02_RS21755 48055..48501 - 447 WP_001074384.1 hypothetical protein -
IAI02_RS21760 48505..49347 - 843 WP_000435064.1 replication initiation protein -
IAI02_RS21765 49368..50207 - 840 WP_024129959.1 replication initiation protein -
IAI02_RS21770 51442..51693 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
IAI02_RS21775 51683..51964 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAI02_RS21780 52203..52295 - 93 Protein_62 IS6 family transposase -
IAI02_RS21785 52461..53660 - 1200 WP_000948429.1 IS91 family transposase -
IAI02_RS21790 53670..53858 - 189 WP_000957857.1 hypothetical protein -
IAI02_RS21795 53978..55408 + 1431 Protein_65 IS4-like element IS50R family transposase -
IAI02_RS21800 55437..56231 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
IAI02_RS21805 56252..56488 + 237 Protein_67 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-IIa / rmtB / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / blaTEM-1B / blaCTX-M-55 / mph(A) / catA2 / aac(6')-Ib-cr / fosA3 - 1..153051 153051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T170952 WP_000220561.1 NZ_CP060749:51683-51964 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T170952 NZ_CP077805:2513530-2513862 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACTCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT170952 WP_000121743.1 NZ_CP060749:51442-51693 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT170952 NZ_CP077805:2513272-2513529 [Klebsiella variicola]
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGACAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References