Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 636615..637318 Replicon chromosome
Accession NZ_CP060744
Organism Klebsiella pneumoniae strain KP120

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag IAI03_RS03000 Protein ID WP_065803899.1
Coordinates 636977..637318 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A377WBK0
Locus tag IAI03_RS02995 Protein ID WP_053274373.1
Coordinates 636615..636956 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI03_RS02955 632157..632861 + 705 WP_065803893.1 WYL domain-containing protein -
IAI03_RS02960 632861..633430 + 570 WP_004929046.1 hypothetical protein -
IAI03_RS02965 633467..633919 + 453 WP_065803894.1 hypothetical protein -
IAI03_RS02970 633916..634365 + 450 WP_071571046.1 hypothetical protein -
IAI03_RS02975 634437..634658 + 222 WP_065803896.1 DUF905 domain-containing protein -
IAI03_RS02980 634757..635578 + 822 WP_065803897.1 DUF945 domain-containing protein -
IAI03_RS02985 635609..636049 + 441 WP_039567646.1 antirestriction protein -
IAI03_RS02990 636062..636604 + 543 WP_065803898.1 DNA repair protein RadC -
IAI03_RS02995 636615..636956 + 342 WP_053274373.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IAI03_RS03000 636977..637318 + 342 WP_065803899.1 TA system toxin CbtA family protein Toxin
IAI03_RS03005 637573..638580 + 1008 WP_004108748.1 restriction endonuclease -
IAI03_RS03010 638948..640059 + 1112 Protein_572 IS3 family transposase -
IAI03_RS03015 640076..640264 + 189 Protein_573 transposase -
IAI03_RS03020 640463..641347 - 885 WP_004192285.1 RES domain-containing protein -
IAI03_RS03025 641358..642030 - 673 Protein_575 DUF4400 domain-containing protein -
IAI03_RS03030 642030..642296 - 267 WP_004178415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 612398..650061 37663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12756.74 Da        Isoelectric Point: 9.0089

>T170912 WP_065803899.1 NZ_CP060744:636977-637318 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIHEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T170912 NZ_CP077777:139836-139985 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12773.41 Da        Isoelectric Point: 6.6253

>AT170912 WP_053274373.1 NZ_CP060744:636615-636956 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT170912 NZ_CP077777:c139791-139732 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A377WBK0

References