Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 78722..79347 Replicon chromosome
Accession NZ_CP060744
Organism Klebsiella pneumoniae strain KP120

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag IAI03_RS00375 Protein ID WP_004187928.1
Coordinates 78964..79347 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag IAI03_RS00370 Protein ID WP_004150355.1
Coordinates 78722..78964 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI03_RS00345 74724..75323 + 600 WP_004151865.1 glucose-1-phosphatase -
IAI03_RS00350 75317..76177 + 861 WP_004146232.1 virulence factor BrkB family protein -
IAI03_RS00355 76174..76611 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
IAI03_RS00360 76656..77597 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
IAI03_RS00365 77611..78528 - 918 WP_004187929.1 alpha/beta hydrolase -
IAI03_RS00370 78722..78964 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
IAI03_RS00375 78964..79347 + 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
IAI03_RS00380 79521..80450 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
IAI03_RS00385 80447..81082 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
IAI03_RS00390 81079..81981 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T170909 WP_004187928.1 NZ_CP060744:78964-79347 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T170909 NZ_CP077774:5005-5271 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT170909 WP_004150355.1 NZ_CP060744:78722-78964 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT170909 NZ_CP077774:4797-5021 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References