170893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 528780..529296 Replicon chromosome
Accession NZ_CP060737
Organism Enterobacter roggenkampii isolate enterobacter cloacae

Toxin (Protein)


Gene name relE Uniprot ID A0A0W2HDR3
Locus tag H9W87_RS02510 Protein ID WP_008501399.1
Coordinates 529012..529296 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag H9W87_RS02505 Protein ID WP_008501400.1
Coordinates 528780..529022 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9W87_RS02490 524870..525610 + 741 WP_021240686.1 KDGP aldolase family protein -
H9W87_RS02495 525636..526772 + 1137 WP_047744915.1 lactonase family protein -
H9W87_RS02500 526792..528702 + 1911 WP_150319493.1 BglG family transcription antiterminator -
H9W87_RS02505 528780..529022 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H9W87_RS02510 529012..529296 + 285 WP_008501399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9W87_RS02515 529300..529764 - 465 WP_045408172.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H9W87_RS02520 529870..532008 - 2139 WP_008501397.1 anaerobic ribonucleoside-triphosphate reductase -
H9W87_RS02525 532378..532950 - 573 WP_047747541.1 fructose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10768.53 Da        Isoelectric Point: 10.3039

>T170893 WP_008501399.1 NZ_CP060737:529012-529296 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHNLPDCYKIKLKASGYRLVYQVQDSVITVFVIAVGK
REKSAAYHDANKRL

Download         Length: 285 bp

>T170893 NZ_CP077763:4532553-4533086 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT170893 WP_008501400.1 NZ_CP060737:528780-529022 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT170893 NZ_CP077763:4532276-4532542 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W2HDR3

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References