Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1089161..1089781 Replicon chromosome
Accession NZ_CP060733
Organism Enterobacter roggenkampii strain Ed-982

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag H9W86_RS05120 Protein ID WP_008499287.1
Coordinates 1089161..1089379 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag H9W86_RS05125 Protein ID WP_008499288.1
Coordinates 1089407..1089781 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9W86_RS05090 1085174..1085434 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
H9W86_RS05095 1085437..1085577 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
H9W86_RS05100 1085574..1086284 - 711 WP_065101748.1 GNAT family N-acetyltransferase -
H9W86_RS05105 1086386..1087846 + 1461 WP_070531477.1 PLP-dependent aminotransferase family protein -
H9W86_RS05110 1087818..1088285 - 468 WP_008499285.1 membrane protein -
H9W86_RS05115 1088403..1088954 - 552 WP_008499286.1 maltose O-acetyltransferase -
H9W86_RS05120 1089161..1089379 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
H9W86_RS05125 1089407..1089781 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
H9W86_RS05130 1090291..1093437 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
H9W86_RS05135 1093460..1094653 - 1194 WP_008499290.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-114)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T170879 WP_008499287.1 NZ_CP060733:c1089379-1089161 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T170879 NZ_CP077760:2811375-2811650 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT170879 WP_008499288.1 NZ_CP060733:c1089781-1089407 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT170879 NZ_CP077760:2811112-2811372 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38


Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References