Detailed information of TA system TA170874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2896177..2896828
• Replicon: chromosome
• Accession: NZ_CP060732
• Organism: Acinetobacter baumannii strain abA1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: H7H20_RS14125
• Protein ID: WP_000838146.1
• Coordinates: 2896646..2896828 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: H7H20_RS14120
• Protein ID: WP_000966689.1
• Coordinates: 2896177..2896581 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7H20_RS14105	2891210..2891551	-	342	WP_001281459.1	phage tail protein	-
H7H20_RS14110	2891669..2895634	-	3966	WP_000191304.1	tape measure protein	-
H7H20_RS14115	2895695..2896096	-	402	WP_000720591.1	hypothetical protein	-
H7H20_RS14120	2896177..2896581	-	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7H20_RS14125	2896646..2896828	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7H20_RS14130	2897160..2897693	-	534	WP_001185622.1	hypothetical protein	-
H7H20_RS14135	2897738..2898667	-	930	WP_000094300.1	hypothetical protein	-
H7H20_RS14140	2898775..2898987	-	213	WP_000121166.1	hypothetical protein	-
H7H20_RS14145	2898989..2899387	-	399	WP_001132270.1	hypothetical protein	-
H7H20_RS14150	2899389..2899757	-	369	WP_000539752.1	hypothetical protein	-
H7H20_RS14155	2899729..2900133	-	405	WP_000248324.1	hypothetical protein	-
H7H20_RS14160	2900142..2900510	-	369	WP_000524231.1	hypothetical protein	-
H7H20_RS14165	2900512..2900901	-	390	WP_000008492.1	hypothetical protein	-
H7H20_RS14170	2900906..2901571	-	666	WP_038337351.1	stress-responsive nuclear envelope protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2873284..2923565	50281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T170874 WP_000838146.1 NZ_CP060732:c2896828-2896646 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T170874 NZ_CP077760:c1959957-1959466 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT170874 WP_000966689.1 NZ_CP060732:c2896581-2896177 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT170874 NZ_CP077760:c1960247-1959954 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8