Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2729237..2729899 Replicon chromosome
Accession NZ_CP060731
Organism Pseudoxanthomonas mexicana strain GTZY2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IAE60_RS12790 Protein ID WP_187572546.1
Coordinates 2729237..2729419 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IAE60_RS12795 Protein ID WP_187572547.1
Coordinates 2729483..2729899 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAE60_RS12770 2724642..2725268 - 627 WP_187572542.1 thioredoxin domain-containing protein -
IAE60_RS12775 2725507..2727294 + 1788 WP_187572543.1 reverse transcriptase family protein -
IAE60_RS12780 2727993..2728373 + 381 WP_187572544.1 fluoride efflux transporter CrcB -
IAE60_RS12785 2728386..2729060 + 675 WP_187572545.1 hypothetical protein -
IAE60_RS12790 2729237..2729419 + 183 WP_187572546.1 type II toxin-antitoxin system HicA family toxin Toxin
IAE60_RS12795 2729483..2729899 + 417 WP_187572547.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IAE60_RS12805 2731624..2732166 + 543 WP_187572548.1 hypothetical protein -
IAE60_RS12810 2732190..2732777 - 588 WP_187574751.1 hypothetical protein -
IAE60_RS12815 2733092..2733436 + 345 WP_187572549.1 helix-turn-helix domain-containing protein -
IAE60_RS12820 2733514..2734095 - 582 WP_187572550.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2520039..2917680 397641
- flank IS/Tn - - 2730266..2731117 851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.19 Da        Isoelectric Point: 11.2176

>T170873 WP_187572546.1 NZ_CP060731:2729237-2729419 [Pseudoxanthomonas mexicana]
MNSRLLRRWLVSLGVQMIEGSRHTKLYYQGKQSTLPRHTQIPDVLVKAILKQLGIVEPPP

Download         Length: 183 bp

>T170873 NZ_CP077760:c1852841-1852557 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15185.52 Da        Isoelectric Point: 6.4796

>AT170873 WP_187572547.1 NZ_CP060731:2729483-2729899 [Pseudoxanthomonas mexicana]
MYRYPARILPDGTGYVVSFRDIPEALTSGSTMEEAIDMARDALATAMDFYFEDRREVPTPSKAKRGEVEIDLSASLSAKV
LLLNEMLREKVTAAQLARKLGTSPQVVNRIVDLHHATKIDTISDALSAMGKRLVMSVA

Download         Length: 417 bp

>AT170873 NZ_CP077760:c1853073-1852831 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References