Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2729237..2729899 Replicon chromosome
Accession NZ_CP060731
Organism Pseudoxanthomonas mexicana strain GTZY2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IAE60_RS12790 Protein ID WP_187572546.1
Coordinates 2729237..2729419 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IAE60_RS12795 Protein ID WP_187572547.1
Coordinates 2729483..2729899 (+) Length 139 a.a.

Genomic Context

IAE60_RS12775IAE60_RS12780IAE60_RS12785IAE60_RS12790IAE60_RS12795IAE60_RS12805IAE60_RS12815IAE60_RS12770IAE60_RS12810IAE60_RS12820
Location: 2725507..2727294 (1788 bp)
Type: Others
Protein ID: WP_187572543.1
Location: 2727993..2728373 (381 bp)
Type: Others
Protein ID: WP_187572544.1
Location: 2728386..2729060 (675 bp)
Type: Others
Protein ID: WP_187572545.1
Location: 2729237..2729419 (183 bp)
Type: Toxin
Protein ID: WP_187572546.1
Location: 2729483..2729899 (417 bp)
Type: Antitoxin
Protein ID: WP_187572547.1
Location: 2731624..2732166 (543 bp)
Type: Others
Protein ID: WP_187572548.1
Location: 2733092..2733436 (345 bp)
Type: Others
Protein ID: WP_187572549.1
Location: 2724642..2725268 (627 bp)
Type: Others
Protein ID: WP_187572542.1
Location: 2732190..2732777 (588 bp)
Type: Others
Protein ID: WP_187574751.1
Location: 2733514..2734095 (582 bp)
Type: Others
Protein ID: WP_187572550.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IAE60_RS127702724642..2725268-627WP_187572542.1thioredoxin domain-containing protein-
IAE60_RS127752725507..2727294+1788WP_187572543.1reverse transcriptase family protein-
IAE60_RS127802727993..2728373+381WP_187572544.1fluoride efflux transporter CrcB-
IAE60_RS127852728386..2729060+675WP_187572545.1hypothetical protein-
IAE60_RS127902729237..2729419+183WP_187572546.1type II toxin-antitoxin system HicA family toxinToxin
IAE60_RS127952729483..2729899+417WP_187572547.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
IAE60_RS128052731624..2732166+543WP_187572548.1hypothetical protein-
IAE60_RS128102732190..2732777-588WP_187574751.1hypothetical protein-
IAE60_RS128152733092..2733436+345WP_187572549.1helix-turn-helix domain-containing protein-
IAE60_RS128202733514..2734095-582WP_187572550.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--2520039..2917680397641
-flankIS/Tn--2730266..2731117851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.19 Da        Isoelectric Point: 11.2176

>T170873 WP_187572546.1 NZ_CP060731:2729237-2729419 [Pseudoxanthomonas mexicana]
MNSRLLRRWLVSLGVQMIEGSRHTKLYYQGKQSTLPRHTQIPDVLVKAILKQLGIVEPPP

Download         Length: 183 bp

>T170873 NZ_CP077760:c1852841-1852557 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15185.52 Da        Isoelectric Point: 6.4796

>AT170873 WP_187572547.1 NZ_CP060731:2729483-2729899 [Pseudoxanthomonas mexicana]
MYRYPARILPDGTGYVVSFRDIPEALTSGSTMEEAIDMARDALATAMDFYFEDRREVPTPSKAKRGEVEIDLSASLSAKV
LLLNEMLREKVTAAQLARKLGTSPQVVNRIVDLHHATKIDTISDALSAMGKRLVMSVA

Download         Length: 417 bp

>AT170873 NZ_CP077760:c1853073-1852831 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References